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Several viral proteins have been identified which encode E3 ligases and promote IRF7 degradation via the ubiquitin-proteasome system.
More than 12,000 genes have been identified, which encode MarR family transcription factors, most of them in eubacteria.
Isoforms of the COX-2 gene have been identified, which encode for the constitutively expressed COX-1 and the inducible COX-2.
Links: The Myelin Project (http://www.myelin.org/), OMIM (http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim) About 85 genes in Homo sapiens and 61 genes in Saccharomyces cerevisiae have been identified, which encode for peroxisomal proteins.
To date, six PARK genes have been identified which encode: α-synuclein (PARK1/4), parkin (PARK2), PINK1 (PTEN-Induced Kinase 1— PARK6), DJ-1 (PARK7), LRRK2 (Pand8) ATP13A213ATP13A2K9).
In the majority of cases it is genetically determined and, in humans, 18 EB-associated genes have currently been identified which encode the structural proteins involved in epidermal and dermal adhesion [ 8].
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Additionally, a putative open reading frame (ORF) in the positive-sense of segment 8 has been identified, which encodes for a hypothetical negative sense protein (NSP) of ~25 kDa (Zhirnov et al., 2007).
A major QTL for grain width, i.e., GW2 on chromosome 2, has been identified; which encodes a RING type protein with E3 ubiquitin ligase activity and is known to function in the ubiquitin-proteasome pathway [ 57].
Sucrose-phosphate synthase and sucrose-phosphate phosphatase were identified, which encode enzymes that act sequentially to synthesize sucrose from UDP-glucose and fructose 6-phosphate.
Indeed, small cytoplasmic domain exons similar to the ones found in human CEACAM3 and CEACAM4 could be identified, which encode ITAM motifs close to the C-terminal end.
Recently, a second TPH gene (TPH2) was identified, which encodes for the main 5-HT-synthesizing enzyme in neurons, whereas the previously known TPH gene (TPH1) is predominantly expressed in peripheral tissues [1], [6].
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