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Strains have previously been identified which do not produce Csp, although the majority do [ 16].
Since then, other AsA-deficient A. thaliana mutants have been identified which do not seem to be affected in any of the known pathway genes [ 4, 5].
Interestingly, a novel class of Keap1 cancer mutations have recently been identified which do not lead to the destruction of two-site binding.
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For acid sphingomyelinase (aSMase) a novel scaffold which exhibits better properties like a lower AlogP value could be identified which do not inhibit the neutral isoform.
In the first, two distinct FASTY hits can be identified which do not overlap and are in opposite orientation.
In addition, a specific site for linker introduction was identified, which did not significantly affect the binding affinity.
In addition to a normal transcript (SV1), an aberrantly spliced transcript (SV2) lacking exon 2 was identified, which did not give rise to a functional protein due to frameshift and a premature termination codon.
Five QTL controlling this trait were identified which did not co-localize with QTL controlling systemic spread.
Finally, a novel Al tolerance source in maize based on ZmMATE1 was identified, which does not rely on copy number variation to maintain high levels of ZmMATE1 expression.
However, as shown in the first known autoradiographic study of deoxyglucose uptake in breast cancer [ 3] (see Fig. 1), central necrotic areas could be identified which did not accumulate tracer and comprised approximately 12.5% of the estimated total tumor volume.
When preferred adaptation options have been identified, which should be done in close consultation with all stakeholders involved in the adaptation process, climate change guidelines for forest managers shall provide descriptions of steps taken or envisaged to implementing these actions to ensure maximum responsiveness to climate change impacts on forests.
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CEO of Professional Science Editing for Scientists @ prosciediting.com