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Recently, SMLs have been identified which bind in this allosteric binding pocket (reviewed in [ 9]).
Recently, SMLs (small-molecule ligands) have been identified, which bind in an allosteric binding pocket within the transmembrane domain.
A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue.
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More recently, an anti-activator QslA was identified, which binds to LasR via protein-protein interaction and prevents the interaction of the latter with promoter DNA of the las responsive genes.
A novel IL-10 responsive signal molecule, termed IL-10E1, was identified which binds the HTE-1 element of the TIMP-1 promoter.
From a chemical library screen, a small molecule, RITA (reactivation of p53 and induction of tumour cell apoptosis), was identified, which bound to p53 and induced its accumulation in tumour cells (Issaeva et al, 2004).
This sequence, C/T TAA C/T NGCT (N168), was predicted to be a novel transcriptional element but no transcription factor has yet been identified which binds to this element.
To date, two isoforms of the ERs (α and β) have been identified which are able to bind to DNA as homo- or heterodimers.
Various activating ligands were identified, which may bind with a distinct affinity to VEGFR family members.
A PTH-rP-derived peptide, designated PTR-4 was identified, which is capable to bind HLA-A2.1 molecules and to generate PTH-rP-specific cytotoxic T cell (CTL) lines from healthy HLA-A2.1+ individual peripheral-blood-mononuclear-cells (PBMC).
Moreover, in epithelial cells of the Drosophila germ band, several distinct plasma membrane pools of E-Cadherin have been identified, each of which bind different populations of Actin [ 29 ].
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