Several chemical inhibitors of E10 inclusion have been identified through high throughput screening and could provide drug leads (27, 28).
In addition, the presence of a number of phenolic acids, including gallic, syringic, benzoic, trans-cinnamic, p-coumaric acids, and flavonoid compounds such as catechin and kaempferol, has been identified through high performance liquid chromatography (HPLC) analysis [ 19], further confirming TH's scientific importance for human health and medicine.
Indeed, a number of novel small molecule inhibitors of HIF have been identified through high-throughout screening of the National Cancer Institute (NCI) chemical repository or natural product-like combinatorial library [19] [23].
However, >70% of miRNA targets have been identified through high-throughput screenings (such as microarray, mass spectrometry and sequencing, Figure 2D), thus partially reducing the bias.
Interestingly, a glp1_v1-like transcript described here for the salmon louse has recently been identified through high-throughput transcriptome sequencing as a sex-specific variant termed AQP3 in a different parasitic copepod, Caligus rogercresseyi [ 63].
The canonical Wnt/β-catenin pathway has been investigated extensively as a target in cancer treatment and several specific inhibitors of this signaling pathway have been identified through high-throughput screening.
Two proteins were identified through high resolution measurement and top-down MS/MS experiments.
More miRNAs are being identified through high throughput sequencing and various other methods and this information is being deposited in the rice miRBase database.
For instance, the signature of specific processes such as tRNA remolding or recruitment can be most easily recognized when such events have occurred recently, since remolded or recruited tRNAs can be identified through high similarity scores and phylogenetic analyses [ 27, 28].
In particular, the weak bonding interface formed in the layered extrusion process was identified through high-resolution X-ray CT scanning.
Piscine reovirus (PRV) was identified through high-throughput pyrosequencing of serum and heart tissue of experimentally infected fish using novel frequency analysis methods as well as standard alignment methods.
