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Retinitis pigmentosa (RP) refers to a subset of inherited retinal degenerations, for which over 180 disease associated loci have been mapped and of these over 130 genes have been identified that when mutated result in severe vision impairment.
In contrast, a number of genes have been identified that, when mutated, cause familial ALS.
In addition to basic NLSs, several other small epitopes have been identified that when phosphorylated can promote nuclear import.
For example, individual metastasis suppressor genes have been identified that, when lost or mutated, are permissive to the metastatic or invasive phenotype [ 5, 6].
In conclusion, using a silicon microreactor coated with ATM, four carbonyl VOCs in exhaled breath have been identified that when at elevated concentrations reliably diagnose lung cancer.
In C. elegans, genes have been identified that when knocked-down by RNA interference (RNAi) result in defects in growth, larval arrest, morphology, movement or reproduction [ 36].
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A sequence of 4 residues in the third intracellular loop of the D2 receptor was identified that when mutated abolished the receptor/arrestin interaction and internalization39.
From these studies, it was identified that when Au is present as very small particles, with a mean diameter below 10 nm, it becomes surprisingly catalytically active, especially at low temperatures.
By means of innovative proteomics, genomics, and bioinformatics approaches, novel discriminative markers can be identified that, when added to the current serum assays, can improve the DR and FPR [7] [12].
When using smaller sample sizes, positively selected amino acid sites are identified that when the sample size is increased are no longer identified.
An acetal-based cross-linker was identified that, when employed in conjunction with a poly ethylene glycol) (PEG) macromonomer, provided highly controlled BASP formation reactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com