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In actinobacteria, two different regulatory systems have been identified that regulate the transcriptional response to nitrogen limitation, AmtR, a TetR-type transcriptional regulator and GlnR, an OmpR-type transcriptional regulator [ 11– 13].
While much is known about muscle spindle structure, innervation and function, relatively few factors have been identified that regulate intrafusal fiber differentiation and spindle development.
A number of RNA binding proteins have been identified that regulate the stability and translation of AU-rich containing mRNAs.
To date, at least three HIFα (HIF1α, HIF2α, and HIF3α) have been identified that regulate transcriptional programs in response to low oxygen levels.
Although HIF activity is mainly controlled by ubiquitination and protein degradation by the von Hippel Lindau (pVHL) tumor suppressor gene other mechanisms have recently been identified that regulate HIF signaling independently of pVHL.
By using different molecular and genetic approaches, including a mutagenesis screen, several genes have been identified that regulate the response of this organism to acute anoxia (i.e., tps1 [7], ADAR [6], [8], and fau [9]).
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Two plasmodesmal-localized β-1,3 glucanases (PdBGs) were identified that regulate callose accumulation and the number and distribution of lateral roots.
In Arabidopsis, several genes were identified that regulate trichome initiation and development.
Together, these results suggest that specific gene products should eventually be identified that regulate cell type and domain-specific affects.
A total of 53 genes were identified that regulate progression through cell cycle, cell proliferation, cell differentiation, chromatin remodeling, or are known tumor suppressors or oncogenes.
Indeed, for individual cases of functional amyloid, control mechanisms could be identified that regulate the aggregation process via binding proteins or post-translational modifications (Chamot-Rooke et al., 2011 ; Fowler et al., 2007 ).
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