Further, genetic variants have been identified that could negatively impact TFV activation, thereby compromising TFV efficacy in HIV treatment and prevention.
To date, different pathogenic mechanisms have been identified that can profoundly impact the epigenetic derangements in rheumatoid arthritis synovial fibroblasts, including increased consumption of S-adenosylmethionine, a principal methyl donor in DNA methylation reactions, together with deregulation of crucial DNA -and histone-modifying enzymes.
A number of other factors have been identified that have a negative impact on the treatment adherence of patients with diabetes, and there have been a number of systematic reviews of studies investigating interventions with the aim of improving adherence [ 31, 33].
"No significant impacts have been identified that would lead the head of planning to recommend refusing this proposals".
Using the theory of planned behaviour [ 5] to understand the impact of performance feedback to interdisciplinary teams, several factors key to newly-forming interdisciplinary primary care teams were identified that may moderate the impact of such performance feedback.
Several factors are identified that may moderate the impact of a high-density environment on perceptions of crowding and the subsequent experience and effects of stress.
In order to fine-tune application rates, biostimulant-plant specificities and techniques is identified that may yield highest impact on stress protection; high priority should be given to better understanding of the causal/functional mechanism of biostimulants.
Services were identified that would have the greatest impact on major health problems, be achievable given the limitations in infrastructure, be cost effective, and give equal access to health care in both rural and urban areas.
Based on these results, several important improvements in pretreatment and hydrolysis conditions were identified that may have a positive economic impact for a process employing a catalyzed oxidative pretreatment.
Although several genes have been identified that significantly impact breast cancer risk when mutated or aberrantly expressed, only a small fraction of the overall population risk can be attributed to these genes [ 10- 12].
