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Accordingly, several CD8+ T cells reactive to HLA-A*02 myelin epitopes have been identified in peripheral blood of MS subjects [14].
Treg cells have been identified in peripheral blood and synovial tissue of patients with RA [ 80- 82].
Eleven splice variants of DR3 mRNA have been identified in peripheral blood lymphocytes, and upon activation by phytohaemagglutinin (PHA), the transcript level is up-regulated [ 7, 8].
Circulating tumor cells (CTCs) have been identified in peripheral blood (PB) of patients with breast cancer and their presence has been associated with poor disease outcome [ 1– 4].
Distinct miR signatures have been identified in peripheral blood samples from patients with IBD compared with controls and in patients with CD compared with those with UC.
DNA methylation variability regions (MVRs) across the oestrogen receptor alpha (ESR1) gene have been identified in peripheral blood cells from breast cancer patients and healthy individuals.
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Proliferation in the mature rodent RPE was identified in peripheral regions and it has been proposed that some of these cells migrate centrally to compensate for age related cell loss [9], [25].
In the present study, we observed significantly lower proliferative responses to T cell stimulation with anti-CD3 in schizophrenia patients compared to controls, demonstrating that physiological differences can indeed be identified in peripheral tissues.
However, the FcRL4+ subset is largely found in tissue, and can only rarely be identified in peripheral blood.
Significant DNA methylation changes were identified in peripheral blood mainly at gene promoters, while in tumors they appeared to cluster at gene bodies.
Distinct subsets of circulating DCs can be identified in peripheral blood, including myeloid dendritic cells (MDCs) and plasmacytoid dendritic cells (PDCs) [ 31].
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