GADD45 has also been identified in complexes with AID and TDG or AID and MBD4.
Components of the death receptor-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets.
Six positively selected sites were identified in complex IV: 178 in subunit COX1, 54 and 187 in subunit COX2, and 55, 155, and 171 in subunit COX3 (Fig. 5a).
Actin was identified in complex with specific subunits of most ATPases, together with four nuclear Arps (4, 5, 6 and 8) in all organisms, with the exception of yeast.
One important function appears to be as members of chromatin complexes, for example, JARID1A is found associated to the PRC2 Polycomb complex, important in establishing repressive chromatin marks during development, and JARID1C can be identified in complexes with other repressive chromatin modulators such as HDAC1/2/REST, or the H3K9 methyltransferase G9a [ 77, 164].
Finally, the α subunit of the human COPI complex has been identified in a complex with PHB (http://bioinfow.dep.usal.es/apid/index.htm).htm
A mutation in ATP5E (ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit) was identified in an Austrian woman with complex V deficiency, and a single gene defect has been identified in the complex V assembly factor gene ATPAF2, resulting in impaired complex V activity.
The box C/D snoRNP component fibrillarin responsible for the methyltransferase activity of the complex has been identified in AGO2 complexes and another box C/D snoRNP core protein, NOP56, in AGO1 complexes [50,51].
