However, several catalytically active smaller isoforms of PARG have been identified in cell lysates, and these account for the majority of endogenous PARG activity [7].
Roles for EZH2 have been identified in cell cycle, cellular differentiation and pluripotency, among many others [ 16].
Two other transforming forms of c-Cbl have been identified in cell lines derived from carcinogen-induced murine lymphomas, namely 70Z Cbl and p95Cbl [ 33, 34].
Mutations in PTEN have been identified in cell lines derived from gliomas, melanomas and prostate tumours and from a number of tumour specimens derived from glial, breast, endometrial and kidney tissue.
SP cells in which other stemness-related genes are upregulated have also been identified in cell lines of various human cancers including HNSCC, one of which was our previous observation [ 32– 41].
γ-Secretase cleaves at multiple sites within the APP TMD, and various Aβ peptide species have been identified in cell supernatants (Aβ33, 34, 37, 38, 39, 40, 42, 43) and cell lysates (Aβ45, 46, 48, 49).
The non-classical secretion pathway is a new phenomenon that has been identified in cells of many mammals and bacteria, but its functional mechanism has not been so far recognized (Hung et al. 2010; Wang et al. 2013).
They have been identified in cells and in nucleocytoplasmic large DNA viruses (NCLDVs) and used for phylogenetic reconstructions.
Consistent with these observations, a basal gene signature has been identified in cells extracted from MMTV/Wnt1 mammary carcinomas [89], [90].
