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We also noted that GWAS have been relatively successful for the traits studied here: over 20 loci have been identified for type 2 diabetes and around 30 loci have been identified for Crohn's disease [15] and lipid levels [13].
For example, more than 35 susceptibility loci have been identified for type 2 diabetes and 32 for obesity thus far.
However, targeting the DFG out conformation per se does not guaranty more favourable selectivity profiles and many unexpectedly cross reacting targets have been identified for type II inhibitors as well.
This association has also been identified for type 2 diabetes (T2D); however when adjusting for body mass index (BMI), the T2D association is lost suggesting that this association is a secondary effect of BMI [ 1].
Typically, many genetic regions contribute to increased risk of complex disease (20 loci have been identified for type 2 diabetes and 40 for Crohn's disease), but the effect at each region is weak (5-105-10%riske in risk) and seems to be additive and independent.
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Gene expression profiles were downloaded from the Gene Expression Omnibus, and differentially expressed genes (DEGs) were identified for type 2 diabetes.
Two different release mechanisms have been identified for R type domains in fungal NRPSs, indicating the possibility of R domains subtypes.
Catalytic residues have not been identified for RING/UBOX type ligases and are presumed not to exist.
While both stem cell types have the ability to self-renew and differentiate, adult stem cells require niche cells to maintain their "stemness", whereas no niche has been identified for any type of CSCs.
So far no genes have been identified for tension-type headache or cluster headache.
Cancer treatments using stem cells expressing therapeutic genes have been identified for various types of cancers.
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