It is possible that multi-unit recordings are limited in their sensitivity as a particularly responsive neuron can cause an entire cluster to be identified as responsive when the majority of units are unresponsive.
Lipid, fatty acid, and bile acid metabolism pathways were identified as responsive to CR in mouse serum by these authors.
Based on the above-mentioned classification, a total of 230 patients (53%) were identified as responsive, with 5- and 10-year RFS rates of 90.4 and 86.0% respectively.
Applying the linear models for microarray data (Limma model) [ 25], 2179 and 3193 genes were identified as responsive to A. euteiches at 6 hpi and 20 hpi, respectively, while 1610 and 1826 genes were found as responsive to P. pisi at 6 hpi and 20 hpi, respectively (P ≤ 0.05) (Table 1, Additional files 2 and 3).
When ADAS-cog, MMSE and CDR-SB items are considered, similar item combinations are identified as responsive to disease progression despite the diversity of the populations and methodology, indicating that the majority of MCI subjects in clinical studies have a common symptom profile over time.
In agreement with studies from both herbaceous and woody plants, a number of common drought-responsive genes were identified, as well as a few not previously reported.
Also noteworthy is the up-regulation of several probes that are annotated to non-immune related genes that have been identified as viral responsive genes (VRG) by Krasnov et al. [ 54].
The full list of differentially-regulated genes is provided in Additional file 2. Amongst the genes differentially-regulated by salinity, we could identify a substantial number that had previously been identified as salt responsive in tomato [ 27], including several transcription factors, cell wall proteins and cell wall-modifying enzymes and various stress-related genes.
However it is noteworthy that among these 11 probes which were suppressed by the viral mimic, none have been identified as virus responsive genes [ 54] and are likely not required for the innate antiviral response needed to cope with a subsequent virus challenge.
Third, 13 of the 50 genes listed in Table 1 have also been identified as NGF-responsive in previous microarray studies, suggesting that the identified genes are highly likely to be involved in the differentiation process of PC12 cells, especially during the action of the first stimulation (Table 1) [29]–[31].
