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Many factors that have been identified as drivers are inferred based on being the opposite of a barrier.
Constitutively activated signaling molecules have been identified as drivers of cellular transformation and are the favorite targets for therapeutics [ 69].
A number of transcription factors have been identified as drivers of cancer metabolism (Soga, 2013; Ward and Thompson, 2012).
Visual cues have been identified as drivers of speciation in sexually dimorphic bird species [ 8, 40] while sexual imprinting alone can explain assortative mating in modeling studies [ 41].
A lack of evidence and the influence of underlying assumptions [ 33] that are built into health care and medical education systems have been identified as drivers of the duty-hour restriction process around the world [ 3].
A lack of financial access to health services, the resultant poor health, and the high disease burden of the poor have been identified as drivers of poverty in Uganda [ 13], which demonstrates the importance of minimising the financial barriers to health services.
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Four variables have been identified as driver variables and four variables as dependent variables.
Interestingly, a p27E171* mutant, losing the last 28 aminoacids, has been identified as driver mutation in LBC [ 2].
Several genes included in this region have been identified as driver genes, or most frequently amplified genes [ 3, 7, 18].
To date, as many as 140 genes have been identified as driver genes, and mutations in several genes combine to confer growth advantage to cancer cells.
There is much interest in spliceosome inhibitors as anti-cancer therapeutics, both because spliceosome components (including PRPF8 and SF3B1) have been identified as driver genes in hematological cancers and because cancer cells may have a unique dependence on spliceosome activities.
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been classified as drivers
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