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Circular polarization measured on multiple comets has been hypothesized to stem from light scattering by chiral organic molecules or aggregates (Rosenbush et al., 2007, 2008).
As conditions in the upper mantle would not allow moissanite to be stabilized at the predominant oxygen fugacities near the iron-wustite (IW) reference equilibrium (Ballhaus [1995], Woodland and Koch [2003], Frost and McCammon [2008]), moissanite has been hypothesized to stem from the lower mantle (Mathez et al., [1995]).
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The articular cartilage consists of distinct zones with different cellular and molecular phenotypes, and the superficial zone has been hypothesized to harbour stem cells.
The transition of slowly to rapidly dividing cells has been hypothesized to be characteristic for cancer stem cells [ 20, 24].
Since mammary stem cells have been hypothesized to reside in the basal layer, our observations also support the notion that Wnt1 may stimulate expansion of the mammary stem cell population [94], [95].
Primitive hematopoietic stem cells (HSCs) have been hypothesized to have a more "open" chromatin structure that might help maintain a multipotent state by, for example, allowing transcriptional priming of lineage-affiliated genes [ 10- 12].
Tumor cells with stem-like features have been hypothesized to be, at least in part, responsible for these phenomena [ 16, 17].
Aside from their role in tumor initiation, stem-like cancer cells have been hypothesized to contribute directly to cancer metastasis.
Cancer stem cells (CSCs) or tumor-initiating cells (TICs) have been hypothesized to retain the capacity of self-renewal to regenerate the bulk of a heterogeneous tumor.
Since many types of cancer cells partially inherit the hierarchical structure of the tissues from which they emanate, and are hypothesized to develop from stem like tumor cells, it seems highly probable that increased aneuploidy rates are used as an advantage to a given cell population, e.g. to increase the adaptability of stem or fast-dividing progenitor cells.
Promoters are hypothesized to enhance the growth of stem and intermediate cells, and initiators are assumed to cause stem and intermediate cells to give rise to intermediate and tumor cells, respectively.
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