An Asn175Ser mutation was found to increase thermal stability, presumably due to an additional hydrogen bond which was hypothesized to stabilize the enzyme's heme cavity (Morawski et al. 2001).
TMEM16B is expressed in photoreceptor terminals (Stohr et al., 2009), where CaCCs are hypothesized to stabilize presynaptic membrane potential (Lalonde et al., 2008).
In these instances blocking the interaction between p53 and HDM2 is hypothesized to stabilize p53 leading to pathway activation and growth arrest and/or apoptosis in cancer.
Catalytically, members of this superfamily are hypothesized to stabilize an enolate intermediate in their respective reactions using the conserved arginine in the DRE motif (Scheme 2).
A possible example is as- psbT, which was hypothesized to stabilize the complementary psbT mRNA under oxidative stress conditions (Zghidi-Abouzid et al. 2011).
In cases where mutant enzyme is trapped in the ER due to instability or misfolding, specific binding of a small molecule chaperone is hypothesized to stabilize the correctly-folded enzyme, allowing functional material to leave the ER, and decreasing removal of the protein by ER-associated degradation.
In one case, an ndhB asRNA was hypothesized to stabilize or regulate maturation of the cognate sense transcript, whereas a psbT asRNA was proposed to regulate accumulation of PsbT protein through occlusion of the psbT ribosomal binding site (Georg et al. 2010; Zghidi-Abouzid et al. 2011).
Cross-linking of IgE-FcεRI causes its association with detergent-resistant, liquid-ordered membrane domains, and it is hypothesized to stabilize domains of order-preferring lipids that modulate the local concentration of membrane-bound kinases and phosphatases leading to signal propagation.
Indeed, F-BAR domains have been hypothesized to induce or stabilize the curvature present at the division site during S. pombe cytokinesis (Frost et al., 2009).
The flap appears to have stabilizing and/or protective effects on viral DNA, which has been hypothesized to be due to a specific conformation adopted by the three-stranded region.
