In the macaque, this high-frequency region is hypothesized to include the core field A1 as well as belt fields CL and MM [13].
In a similar manner, genes that required ATM activity to establish the correct direction and timing of expression or were specifically regulated in atm (Fig.7 right side) were hypothesized to include targets regulated by other posttranslational regulators acting more upstream or downstream of ATM/ATR and/or further away from DSB sites, such as Tip60 and ARP4.
Those portions of the genome that seem to be shared are called quantitative trait loci (QTLs) and are hypothesized to include genes that contribute to the risk for alcoholism.
The molecular mechanisms are still not known, and are hypothesized to include insertion of transposable elements, insertion of spliced introns from other genes into mRNA followed by reverse transcription, and genomic duplication [ 41].
Prostigmata were hypothesized to include three main groups: Labidostommatina Krantz, 1978 plus Eupodina Krantz, 1978, Anystina van der Hammen, 1972 and Eleutherengona Oudemans, 1909 [ 11, 13, 14], although Eupodina was placed either as sister group of Anystina [ 11] or as the basal lineage of the remaining Prostigmata [ 13].
Mechanisms for lapatinib resistance are less well established and are hypothesized to include increased expression of AXL, a membrane-bound receptor tyrosine kinase with transforming ability [ 27], enhanced ER signaling through transcription factor FOXO3a [ 28], and upregulation of HER3 transcription [ 20].
A variety of design factors have been hypothesized to play a role, including surface hardness, rotational stiffness, and release torque.
Given that the complication of hearing impairment in patients with CKD is multifactorial, it should be considered in hearing impairment studies of patients with CKD that many multiple contributing factors have been hypothesized to cause hearing impairment, including use of ototoxic medications, hypertension, and diabetes, as well as electrolyte disturbances and hemodialysis itself [ 7– 9].
Numerous ecomorphological correlates among the herbivores have been hypothesized to reflect niche partitioning, including differences in snout shape [ 7, 33, 34, 36- 43, 44] 44], jaw mechanics and tooth shape [ 36, 40, 45, 46], and feeding height stratification [ 12, 13, 33, 34].
Bacterial communities are also essential for maintaining gut homeostasis and have been hypothesized to contribute to various diseases including laminitis.
