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Fish consumption and n-3 polyunsaturated fatty acids (PUFA) have been hypothesized to exert preventive effects toward depressive disorders, but findings are contrasting.
In contrast to alcohol, smoking has been hypothesized to exert anti-estrogenic effects [ 23] and to lower the risk of endometrial cancer in this way.
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Placebos are hypothesized to exert positive effects on medical conditions by enhancing patient expectancies.
The study drug is hypothesized to exert a therapeutic effect in fibrosis and cancer by inhibiting fibroblast activation and thereby altering the pathologic matrix in different disease states.
The soleus muscle in patients with DMD is hypothesized to exert more power during ambulation, which causes hypertrophy or pseudohypertrophy and decrease in muscle mass (Cros et al, 1989).
In breast carcinomas, the up-regulation of survivin has been hypothesized to act as a factor exerting resistance against tamoxifen-induced apoptosis [ 23, 24].
IFs in general and desmin in particular have also been hypothesized to directly bind to genomic DNA and to exert a role in transcription regulation and DNA organization [ 182].
The relationship between the pharmacodynamic action of adalimumab and the mechanism(s) by which adalimumab exerts its clinical effects is unknown but has been hypothesized to involve significant inhibition of the pathologic inflammatory process.
The beneficial effects of BMSCs on heart repair have been hypothesized to be due to paracrine signaling [ 60, 61], but the exact mechanism by which BMSCs exert their action for cardiac improvement remains to be determined.
Generally, the acculturation process has been demonstrated to exert a deleterious effect on Latino health and is hypothesized to occur in a cumulative fashion with accumulation of risk factors over the lifecourse.
191 Furthermore, the reverse geometry design was hypothesized to further reduce the epithelial surface integrity likely because of its compressive hydraulic effect exerted on the cornea, hence increasing its susceptibility to infection.
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