In these studies, KIR3DS1/Bw4-80I genotypes were suggested to directly activate NK cells [10], while strongly inhibitory KIR3DL1/Bw4-80I genotypes were hypothesized to display greater NK cell activation capacity due to better NK cell licensing [17].
With regard to ethnic differences, non-Western offenders were hypothesized to display more individual and family risk factors than Dutch offenders.
Unfortunately, the epigenome study of NPC lags significantly behind that of GC, although nearly all NPC cases are associated with latent EBV infection; hence, NPC is hypothesized to display a unique high methylation/EBV-positive epigenotype.
Particularly, the dispensable chromosomes display a high frequency of chromosomal rearrangements and, in the absence of strong positive selection, have been hypothesized to drive divergence [ 31].
Neurons that are proximal to plaques display aberrant dystrophic neurites with disrupted trajectories indicative of synaptic dysfunction (for example, [ 88]) and plaques have been hypothesized to create and sustain neurotoxic microenvironments [ 89] and perturb mitochondrial function [ 90].
Although the basis of the embryonic lethality is unclear, it was hypothesized to be due to abnormal heart development or function, as the hearts of mutant embryos display greater heterogeneity in cell size and orientation (Thomas et al., 1995).
The "bell/inverted bell shaped" curve displayed by the expression levels of several self-renewal/differentiation genes, found in [14] can now be hypothesized to arise out of these basic interactions.
The model displays that our lactonase enzyme has a putative structure of a metalloenzyme that is hypothesized to contain binding sites for 2 zinc atoms where all the residues interacting with the ligand are completely conserved between model and template.
Several mechanisms were hypothesized to trigger this phenomenon.
