DLGR2, once activated, is hypothesized to activate the cAMP/PKA signaling pathway [ 13].
Regions hypothesized to deactivate under the task; otherwise, the region is hypothesized to activate.
Exposures to infectious agents early in life are hypothesized to activate regulatory pathways in our immune system that suppress development of autoimmunity and thus T1D [ 4].
This is contrary to Aeadsx, which is hypothesized to activate a weak splice acceptor upstream of the female-specific exon 5b [ 18], and Angdsx which likely relies on activation of the 5' weak splice donor downstream of exon 5 [ 27].
Differential expression of the proximal ER stress sensor HSPA5 is reported in human IBD tissues (Bogaert et al., 2011), and ER stress is hypothesized to activate pro-inflammatory signals through multiple mechanisms (Deng et al., 2004; Hu et al., 2006; Yamazaki et al., 2009).
These high levels of catecholamines have also been hypothesized to inhibit insulin secretion and to activate lipolysis of adipose tissue resulting in increased plasma FFA [ 12, 13].
Aberrant hypomethylation has been hypothesized to contribute to cancer progression by activating oncogenes such as h-RAS, r-RAS, c-MYC, and c-FOS [11] [13], by retrotransposon activation [14] [16] or by increasing chromosome instability as in ICF syndrome [17].
The existence of two different PTN isoforms has been hypothesized to explain the discrepancy in reports concerning the ability of PTN to activate ALK.
unf has been hypothesized to act as a transcriptional repressor, because its ligand-binding domain (LDB) failed to activate gene expression [66].
Because activation of ARs reduces both immune and inflammatory responses, adenosine release has been hypothesized to be a possible mechanism of cell self-protection from activated neutrophils [ 5].
