Sentence examples for been hypothesized that stem from inspiring English sources
It has been hypothesized that stem cells are more abundant in tumours than in normal mucosa [ 2, 19] and we also observed that there was a clear overexpression of LGR-5 compared to the normal mucosa in MDF and tumours.
It was hypothesized that stem cells undergo asymmetric division, giving rise to two progeny: one destined to remain as an undifferentiated stem cell (self renewal) and one that could go on and divide again to give rise to progeny that expand in number and undergo differentiation.
It has been hypothesized that cancer stem cells possess a high degree of plasticity, and that following EMT, E-cadherin expression may be restored without losing stem cell function or invasive capacity [ 36].
It has been hypothesized that the stem cell repertoire of adult tissues generally consists of a small number of self-replenishing cells that differentiate from primate bone marrow cells [ 14].
It has been hypothesized that the mammary stem cells responsible for establishing the mammary architecture during puberty are directly responsible for all subsequent mammary proliferation [ 37, 38].
It has been hypothesized that this effect stems from a net change in average junction distance between the conductive particles when the overall material is strained.
It has been hypothesized that medulloblastoma tumors contain stem cell-like tumor-initiating cells that are more resistant to therapy [ 33, 34].
It has been hypothesized that an ER- stem cell population gives rise to ER+ progenitor cells [ 40], which will proliferate when exposed to estrogen, but can also send paracrine signals that will cause neighboring populations of ER- cells to proliferate.
It has been hypothesized that the capacity of stem cells to maintain tissue homeostasis functionally declines with age, and that this decline may be responsible for many of the biological phenotypes associated with aging (reviewed in Van Zant & Liang, 2003).
It has therefore been hypothesized that a customized femoral stem could fulfill the criterion for optimal fit and fill, and thus minimize stress shielding in the proximal femur (Bargar 1989).
