Based on the established druggability of p38 as a target, its diverse role in cellular function and the specific role for MK2 in TNF production it has been hypothesized that specific modulation of this interaction would lead to an improved safety profile over previous p38 inhibitors.
It has been hypothesized that the fast modulation of milk secretion in response to external factors, such as emotional stress, and harsh physical conditions such as heat stress and water deprivation also depends on such a negative-feedback regulatory system, which increases the potential for survival in response to stress [ 19, 20].
It has also been hypothesized that the beneficial effects of 17β-estradiol in these disorders are mediated, in part, through the modulation of neural circuitry (Frick, 2012; Gillies and McArthur, 2010; Hughes et al., 2009; Srivastava and Penzes, 2011).
It has been hypothesized that sorafenib could exert a dual activity: the first one directly on neoplastic cells and the second one trough a modulation of pro-thrombotic cytokines [ 16].
We thus hypothesized that modulations in insulin signaling could be involved in mitochondrial biogenesis observed in DNP and CR animals.
On the basis of the observations, it may be hypothesized that there is a possible modulation of FAS and PTP-1B signaling in protective effect of B. ceiba extract against HFD induced obesity and this may be due to the potency and efficacy of reported active phytoconstituents present in it.
Between 1970 1980, it was hypothesized that the involvement of brain regions in the modulation of nociceptive primary afferent inputs originated from the peripheral nervous system [ 16].
For this reason, it can be hypothesized that CGRP plays a determining role in CSD and its modulation may be effective for the preventive treatment of MwA (Figure 2).
Therefore, it can be hypothesized that 1 α,25(OH)2D3 may contribute to myogenesis by inducing IGF-II expression through modulation of myostatin-follistatin system.
