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Some studies have shown a benefit from combining chemotherapy and ABT-737, so far, the molecular bases of this interaction are not well-known although it has been hypothesized that induction of Noxa by CPT-11 in colorectal carcinoma or Mcl-1 downregulation by various chemotherapy regimens may explain positive interaction.
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The performed analysis also identified some anti-cancer drugs for potential use in CF patients [ 89, 90] and it was hypothesized that induction of homologous recombination in respiratory epithelium helps to improve the lung function of patients [ 90].
Therefore, it was hypothesized that: H1.
In regard to nuclear medicine literature reporting lung uptake of colloidal radiopharmaceuticals in patients with liver diseases, it has been hypothesized that liver abnormalities could trigger induction of pulmonary intravascular macrophages (PIMs) in humans normally lacking them.
It has been hypothesized that cAMP analogues act to mimic the induction of stumpy formation, bypassing the initial step(s) of environmental density sensing and triggering at least part of the stumpy induction signaling cascade within the cell.
It has been hypothesized that exposure to atrazine may alter hormone levels, possibly through induction of aromatase, which converts androgens into estrogens (Gammon et al. 2005).
It has been hypothesized that the CR-mediated reduction in body temperature relates to the induction of an energy conservation mechanism during CR [ 11].
Consequently, it has been hypothesized that sCLU gene silencing using siRNA or other techniques may ultimately develop into attractive antitumor apoptotic induction [ 294].
Here, it was hypothesized that DSB induction close to a targeted mutation in the genome of a mammalian cell might attract oligodeoxynucleotide (ODN -directed gene repair.
However, since the protein is localized predominantly in the mitochondria of transfected or infected cells and found to alter the mitochondrial morphology [4] it was hypothesized that apoptosis induction occurs due to direct interaction with subunits of the mitochondrial PTPC or destabilisation of the mitochondrial membrane by pore formation [10].
It is hypothesized that SA induction and low light caused V. longisporum-induced stunting mediated by the seasonally influenced QTL stre1, stre2 and r-stre3 (see Discussion).
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