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It has been hypothesized that expression variances of regulatory key genes contribute to the individual phenotype of the given disease [ 17], whether independent of or depending on the expression level.
Interestingly, Buchnera aphidicola, an obligate mutualistic γ-proteobacterium associated with aphids, has all the components to synthesize the bacterial cell wall, except ldcA, and it has been hypothesized that expression of this nuclear-encoded gene in the bacteriocyte may allow aphids to control growth of its endosymbiont by manipulating biosynthesis of the endosymbiont's cell wall [ 23].
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It is hypothesized that expression of PTHrP and PTHrP receptor (PTHrPr) offer an advantage in the genesis of bone metastases in prostate cancer through paracrine and autocrine mechanisms.
Based on the above facts, it is hypothesized that expression pattern of genes that are involved in the development of cardiac neural crest is altered, leading to congenital heart defects in embryos of diabetic pregnancy.
It is hypothesized that expression is the result of the balance between Polycomb and Trithorax activity at a given gene, and some cell types may possess additional regulators that can affect gene expression once that balance has been perturbed [ 38, 39].
It is hypothesized that gene expression steroidogenic enzymes following ACTH treatment is only significantly modulated during long-term stimulation.
It was hypothesized that gene expression profiles of modules were up- or down-regulated in a manner that contributed to the muscling phenotype of the sire group.
Expression of Gata6 is significantly depressed in most human adrenocortical tumors [ 46, 47] and it has been hypothesized that decreased expression of Gata6 may be an important event for the escape of tumor cells from normal control mechanisms [ 48].
It has therefore been hypothesized that high expression or long exposure to Cre activity might trigger recombination leading to chromosomal rearrangements in mammalian cells in vivo.
During biofilm development, however, it has been hypothesized that the expression of the cid and lrg operons is differentially regulated within individual cells in the biofilm population and that this control dictates which cells are destined for death and lysis and, on the other hand, which cells remain viable [38].
It has been hypothesized that altered expression of aromatase is important in environmentally influenced sex differentiation.
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