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It has long been hypothesized that environmental factors influence the onset and course of autoimmune diseases.
It has been hypothesized that environmental estrogens may play a role in the increasing incidence of breast cancer, testicular cancer, and other problems of the reproductive system.
As outlined in the introduction, it has been hypothesized that environmental influences during vulnerable developmental periods may lead to lasting changes of the epigenome resulting in altered functionality of the lung and/or the immune system.
While the etiology of sCJD remains unknown, it has been hypothesized that environmental exposure to prions might occur through conjunctival/mucosal contact, oral ingestion, inhalation, or simultaneous involvement of the olfactory and enteric systems.
It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women.
It has been hypothesized that environmental skin exposure to polyurethanes in childhood has contributed to the increased prevalence of childhood asthma (Krone and Klingner 2005), but human isocyanate exposure from such products has not been documented, and there are numerous other likely causative factors.
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From the above arguments, it may be hypothesized that environmental exposure to lead increases the risk of PIH by inducing vasoconstriction and placental ischemia or by a direct toxicity on the endothelial cell and the renal function.
84 It is hypothesized that environmental conditions related to poor hygiene (contact with wet slurry and fecal ammonium and microtrauma) favor spirochetal infection and an increased incidence of disease.
Therefore, it was hypothesized that: H1.
It has been hypothesized that the environmental niche of Cronobacter is as a plant commensal [ 37].
For instance, it has been hypothesized that early environmental influences may contribute to the development of obesity.
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