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It has been hypothesized that circulating levels of sFas may be also reflective of risk of subsequent development of ovarian cancer.
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Therefore, it was hypothesized that: H1.
It has been known for over a hundred years that disseminated tumor cells can be found in the circulation of patients with metastatic cancer [12], and it has been hypothesized that these circulating tumor cells (CTCs) may represent cancer stem cells or a high metastatic potential cellular population [13].
It has been hypothesized that changes in circulating factors may contribute, at least in part, to some of these beneficial effects of CR in rodents [ 4].
It has been hypothesized that in premenopausal women, whose circulating estradiol levels generally are above a threshold of about 50 pg/ml (184 pmol/l), endometrial cancer risk is not related to between-subject differences in circulating estradiol levels, but that low progesterone levels may be a more important determinant of risk (Key & Pike 1988).
In the case of AKI and sepsis, it has been hypothesized that early dialysis in sepsis can reduce circulating levels of inflammatory substances and may therefore beneficially impact on the pathophysiological mechanisms of the disease.
It has been hypothesized that the seasonal variation could be due to a seasonal variation in circulating levels of 25(OH D.
It has been hypothesized that CMV either directly infects the vessels of the heart and replicates at low levels, or is delivered to the vessel wall by infected circulating monocytes arriving at sites of cardiovascular injury or inflammation [24].
It has been hypothesized that reducing sunlight by only 1% should eliminate this problem.
It has been hypothesized that mammographic density reflects cumulative exposure to estrogens [ 3]; however, accumulating evidence suggests that the mechanism by which mammographic density influences breast cancer may be independent of circulating estrogen levels [ 4- 6].
To explain these observations it was hypothesized that systemic circulating factors might be involved [ 24].
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