Several mechanisms have been hypothesized, in particular cross-talking with ERα and/or constitutive activation of MAPK leading to the down regulation of ERα, making the tumors insensitive to estradiol and thus to AIs therapies [ 23, 40].
A so-called inflationary phase, an additional phase of strongly accelerated expansion at cosmic times of around 10^{-33} 10^{-33} wasecondshesized in 1980 to account for several puzzling observations that wase unexplained by classical cosmological models, suchypothesizedrly perfect homogeneiny of the cosmic background radiation.
Starting from the simulation results, several retrofit scenarios were hypothesized, in order to achieve NZEB target, and then followed by a cost analysis carried out to reach optimal economic solutions and energy savings.
Several cases of retroprocessing are hypothesized, in some cases involving the complete gene, which could be indirect evidence of the existence of processed paralogs occurring in the mitochondria.
Over the last decade, a role for ED in the CV complications of inflammatory diseases has been hypothesized and several studies were performed in order to evaluate ED as a marker for risk of CV events in patients with chronic inflammatory diseases like RA.
A role for FABPs in fatty acid transport has been hypothesized for several decades, and the accumulated indirect and correlative evidence is largely supportive of this proposed function.
The concept of loss of physiological complexity in illness and during the aging process has been hypothesized by several literature sources [3], [4], [13].
During the same geological period, there were hypothesized splits in several other Iberian reptile and amphibian genera such as Lissotriton [ 25], Alytes, [ 26], and Blanus [ 27], producing in some of them [25 and 27] a similar east-west differentiation pattern.
Several prognostic criteria have been hypothesized to play a role in SCC outcome in the past two decades.
In several reports, it has been hypothesized that the azoreduction is mediated by a flavoprotein in the microbial electron transport chain.
