"It's been hypothesized for many years, but never proven".
It sounds counterintuitive, but a link between the onset of cold weather and heart attacks has been hypothesized for some time, with an array of possible culprits: inflammation from common colds, the stress and indulgence of the holiday season, and higher blood pressure from narrowed blood vessels.
Various mechanisms have been hypothesized for mechanism of elicitation.
A link between CSD and migraine pathogenesis has been hypothesized for more than 40 years [4 7].
A role for FABPs in fatty acid transport has been hypothesized for several decades, and the accumulated indirect and correlative evidence is largely supportive of this proposed function.
A similar association has been hypothesized for cutaneous SCCs, although, to our knowledge, no studies to date have combined sensitive HPV DNA detection techniques with epidemiologic data controlling for known risk factors to explore the association.
The use of human stem cell treatments for the reconstruction of the endometrium following substantial damage and IUA formation has been hypothesized for some time [96], with studies from animal models showing substantial promise in this area of medical treatment [97, 98, 99].
The work also helps confirm an idea that has been hypothesized for 30 years but never conclusively documented in the field: Not only can mountain-building affect climate (by changing weather patterns, for instance), but, surprisingly, climate can also affect mountain-building.
Removal of the oxygen inhibition layer from the surface of resin-coated gutta-percha cones during packaging has been hypothesized for their weak adhesion to a methacrylate-based root canal sealer, resulting in their frequent delamination from the sealer after root canal obturation.
Evidence for comparable manipulations of bacteria has been hypothesized for birds.
Several potential explanations have been hypothesized for an inverse association between asthma and lung cancer [45].
