It may be hypothesised that reduced fearfulness has been a major target of selection during domestication.
5 It is hypothesised that reduced T-cell signalling may occur as a result and, in turn, this may enable auto-reactive T cells to escape deletion during thymic selection and thus persist in the circulation to become activated at a later stage.
It is hypothesised that following implementation of the behavioural sleep intervention, the number of nocturnal awakenings and maternal depression, anxiety and stress will be significantly reduced.
45 46 It has also been hypothesised that, by reducing the proliferative potential of vascular smooth muscle cells, cellular senescence promotes the thinning of fibrous caps and the instability of atherosclerotic plaques.
It has been hypothesised that exercise training reduces C-reactive protein levels by reducing cytokine production in fat and by increasing insulin sensitivity [ 28].
It has been hypothesised that ventilation combining reduced tidal volumes with extracorporeal carbon dioxide removal (ECCOR) may result in further improvements in mortality[4], and prospective randomised trials are planned [5].
It has been hypothesised that programmes to reduce readmissions may be more effective if resources are applied differentially according to a patient's relative risk of readmission.
It has been hypothesised that benzodiazepines trigger depression by reducing central monoamine activity [ 43].
For example, it has been hypothesised that dopamine dysregulation resulting from reduced gene dosage arising from the deletion could lead to brain disconnectivity and in turn to predisposition to the cognitive and psychiatric deficits for a subgroup of individuals with 22q11.2DS.
It has been hypothesised that patients with PM and IM phenotypes generate reduced plasma concentrations of active metabolites from a standard tamoxifen dose, hence reducing its efficacy.
