Importantly, all 7 serotypes have been shown to be highly lethal in non-human primate models [3].
H5N1 HPAIVs have also proven to be highly lethal in humans: 262 fatalities from 440 reported cases, representing a mortality rate of about 60%, as of August 31, 2009 [6].
The syndrome of disseminated toxoplasmosis is affecting more than two organs and it is highly lethal in HIV positive patients.
Pathogenicity varies among Ebola viruses, from ZEBOV, which is highly lethal in humans, to REBOV, which causes disease in pigs and macaques but asymptomatically infects humans.
Most importantly, ANDV was shown to be highly lethal in Syrian hamsters, and the characteristics of the disease closely resembled HPS in humans (15 ).
The US case fatality of less than 5% for a poisoning that is highly lethal in most other countries may reflect several factors.
While CRISPR directed double-stranded DNA breaks are highly lethal in many bacteria, we show that CRISPR-guided nickase systems can be programmed to make precise, nonlethal, single-stranded incisions in targeted genomic regions.
For some decades most of the limelight in the malaria field has been on the treatment of acute P. falciparum malaria, because this condition is highly lethal, especially in children.
In most clinical studies of deliberate self-harm and suicide attempts in Ethiopia, attempters commonly used organophosphate pesticide [ 22, 27, 62], which is highly lethal and can be taken impulsively in situations of interpersonal disputes [ 63].
Biovar Microtus strain 201 used in this study is highly lethal to mice, but avirulent to humans.
