Sentence examples for been highly implicated from inspiring English sources

The role of two cysteine proteases; caspase and calpain has been highly implicated in programmed cell death in many cell systems [12], [13].

IGF-1 signaling has been highly implicated in development of cancers, especially epithelial cell cancers (carcinomas).

PR has been highly implicated in breast cancer by functioning as the nuclear receptor for the sex hormone progesterone.

Candidate genes such as the serotonin transporter SLC6A4 and BDNF have been highly implicated in stress response and in increased risk for psychiatric disorders [ 28– 328.

EGFR and its signaling, as well as high expression levels of cortactin, have been highly implicated in the aggressiveness of HNSCCs and the poor prognosis of patients [ 7- 10].

Oxidative stress-induced modification of plasma lipoproteins, especially low-density lipoprotein (LDL) and elevated cholesterol level, has been highly implicated among the multiple causative factors of atherosclerosis [ 2– 5].

The coordination of macromolecular assemblies in DNA repair pathways is yet another task disordered protein regions are highly implicated in.

AY rats show spontaneous SSWD involving the hippocampus, a structure that is highly implicated in learning and memory.

This region was identified through the BOLD response t-test and was chosen because right inferior gyrus is highly implicated in response inhibition.

Caspase-3 is an apoptotic cysteine protease and its aberrancy is highly implicated to numerous diseases thereby rendering caspase-3 activity as an important disease marker.

Finally, this article addresses potential interventions designed to control segments of classical inflammatory cascades in the brain in which cyclooxygenase is highly implicated.