Whole genome sequencing (WGS) has revolutionized the subtyping of Legionella pneumophila but calling the traditional sequence-based type from genomic data is hampered by multiple copies of the mompS locus.
However, despite the significant overall difference (p = 0.0001) between the individual genotypes, these results are hampered by multiple comparisons and a small number of cases in each strata.
Identifying the genes that affect chronic disease risk can be hampered by multiple factors, including phenotypic complexity, multiple genes with small effects, environmental variability, gene gene interactions, and gene environment interactions.
Estimation of evolutionary ages for crown clades such as the lizard family Lacertidae may be hampered by multiple sources of uncertainty, including unknown phylogenetic relationships, lack of an adequate fossil record, and variable evolutionary rates.
Transforming the conceptual ideas of biogeochemical cycling into spatially explicit context has been hampered by ecosystem complexity, multiple nested levels of interrelated physical, biological and chemical processes, and the lack of sufficient quantitative data.
Gene expression studies have been hampered by the presence of multiple HSC subtypes and contaminating non-HSCs in bulk HSC populations.
Previous identification of the epicardial-derived caSMC progenitor had been hampered by the fact that multiple developmental pathways occur downstream of epicardial differentiation.
Positional cloning strategies have been hampered by the paucity of large families with multiple affected members.
One of the main strategies of systems biology, the integration of genome-wide data generated by multiple orthogonal proteomic techniques [27], has been hampered by incomplete datasets.
Further investigation into the evolution of sesame has been hampered by the absence of detailed molecular data across multiple sesame strains.
