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Their proliferation might have been hampered by methodological challenges such as the difficulty applying existing statistical procedures.
The UK NTS data does meet the majority of this demanding data requirement, but its full use has so far been hampered by methodological difficulties.
Further, the study of efficacious treatments has been hampered by methodological challenges (e.g., overreliance on "superiority" designs (i.e., designs structured to test whether or not one treatment statistically surpasses another in terms of effect sizes) and short term interventions).
Despite these observations, research in the field has long been hampered by methodological limitations.
Previous studies and estimates have been hampered by methodological issues including small sample sizes and lack of objective measures.
Research in this field has been hampered by methodological weaknesses, whereof the most prominent has been sampling bias.
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Alternatively, the mutagenic potency of fecal extracts has been determined, but the interpretation of these more integrative measurements is hampered by methodological shortcomings.
The comparison of results among studies is hampered by methodological differences.
However, the surveillance commonly applied is hampered by methodological pitfalls that impede the interpretation of the surveillance findings [ 2].
The interpretation of the causal association is hampered by methodological challenges and limited number of studies on dose response.
However, study of the impact of these drug categories is hampered by methodological flaws that fail to take into account the use of more than one drug.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com