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Similarly, a number of Leishmania mutants have been generated with defects in pathways for de novo synthesis of other metabolites (glycine, amino sugars) or nutrient salvage pathways (nucleotide/nucleoside/purine base) that retain virulence in animal models, suggesting considerable redundancy in nutrient uptake/ de novo biosynthetic pathways.
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Animals can be generated with defects in any of these or similar domains by a variety of manipulations, including pharmacological, surgical, experiential and genetic.
Pictures have been generated with MacPyMOL.
Multibarplots are generated with QIIME25.
DNA damage was generated with genotoxic stress.
Graphs were generated with Microsoft Excel program.
The effect of the defect size has been correlated with the ASTM grade and a Kitagawa-Takahashi diagram has been generated for surface defects.
Furthermore, a mouse model overexpressing FRG1 has been generated, displaying skeletal muscle defects.
Two mouse models of TK2 defects have been generated.
Serial sections were generated through each defect; approximately 100 slides were made through each defect.
In ceh-19 tm452 ceh-19 tm452e mutantss are generathe, but with obvious axonal MCrphologicellsefects, suggesting CEH-19 is required for proper specificareon of the MC neuronal type.
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