Through this process, numerous oligonucleotide probes (aptamers) have been generated that can bind specifically to proteins associated with membranes of different tumor cells [19], [20], [21], [22], [23], [24], [25], [26].
A number of human diseases with mutated podocyte components have also been identified and several mouse models have been generated that have facilitated our understanding of podocyte biology [7] [14].
Many schemes have been generated that rely on both clinical and electrographic findings.
Feeder-free cell culture systems have been generated that can be adopted for clinical use [ 46].
Many neutralizing MAbs to botulinum toxins have been generated that have potential diagnostic and therapeutic applications (21– 21).
Recently, a survival-adjusted cumulative mean function model has been generated that can provide an intuitive graphic representation of skeletal morbidity throughout a study.
However, with the use of genes from specific defence regulons as promoters, strains have been generated that have enhanced sensitivity for oxidative compounds.
In the past few years a panel of genetically engineered mouse models have been generated that could rapidly address these differences [ 16].
Interestingly, hypomorphic WNK4 mice have recently been generated, that also display reduced blood pressure and lower levels of SPAK/OSR1 and NCC phosphorylation (Ohta et al, 2009).
A lox-p flanked conditional Glut1 allele has now been generated that can be utilized to study GLUT1 in specific cell types, such as CNS endothelial cells [ 43].
Until now, only conventional major vault protein-reactive murine monoclonal antibodies have been generated, that are most suitable for immunohistochemical analyses.
