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Induced pluripotent stem (iPS) cells have been generated from mouse and human fibroblasts by the retroviral transduction of four transcription factors.
Induced pluripotent stem (iPS) cells have been generated from mouse and human somatic cells by introducing Oct3/4 and Sox2 with either Klf4 and c-Myc or Nanog and Lin28 using retroviruses or lentiviruses.
Hematopoietic cells including cells of the erythroid lineage have been generated from mouse [4] [7], non-human primate [8] [10], and human ES cells [11] [16].
Although the complete chemical reprogramming approach remains to be further explored for reprogramming of human somatic cells, chemically induced pluripotent stem cells (CiPSCs) have already been generated from mouse somatic cells, using a combination of seven small molecule compounds [29].
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A recent study showed that pluripotent stem cells can also be generated from mouse somatic cells by using a cocktail of small-molecule compounds3.
The recent discovery that induced neuronal (iN) cells can be generated from mouse and human fibroblasts by expression of defined transcription factors suggested that cell fate plasticity is much wider than previously anticipated.
Indeed, research has already shown that transplantable dopaminergic neurons the kind of neurons affected in Parkinson disease can be generated from mouse, primate, and human ESCs.
DCs were generated from mouse bone marrow cells cultured with Fms-like tyrosine kinase-3 ligand and stimulated with a wide array of individual TLR agonists or simultaneously with pairs of combinations.
The anti-human FXYD6 mAb of FD10 was generated from mouse.
Mature, fully functional female gametes can be generated from mouse pluripotent stem cells.
Skeletal muscle data used in the meta-analysis was generated from mouse, rat, and human tissues, providing evidence that the results are consistent across species and platforms.
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