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In recent years novel insights into nucleosome assembly of new H3 H4 tetramers have been gained through studies on the classical histone chaperone CAF-1 and the identification of novel factors involved in this process.

Significant insight on the role of basal ganglia for grasp control has been gained through studies of patients affected by Parkinson's disease (PD) (e.g., [14] [18]).

Valuable insights have been gained through studies of An. gambiae [15] [16] and the sequencing of its genome [17], but An. gambiae is just one of several potent vectors of human malaria in Africa, and many open questions remain, including those regarding the genetic similarities and differences between the three most important and congeneric vectors: An. gambiae, An. arabiensis and An.

New insights into this process have recently been gained through studies in vitro (Rieger et al., 2009); however, whether GFR signaling instructs lineage specification in vivo remains a key unresolved issue (Enver and Jacobsen, 2009).

Major insights into the molecular mechanisms of circadian oscillators have been gained through studies of the model organism Neurospora crassa; however, little is known about molecular components of circadian clocks in other fungi.

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While studies of the disease in naturally infected field cases of bovine tuberculosis have provided valuable information, detailed knowledge can also be gained through studies of disease models.

Insight into such mechanisms can be gained through study of the relatively few proteins that aggregate under native conditions.

A better understanding of the reprogramming of mitochondrial genes during development might be gained through studying iPS cells and differentiated cells of interest.

A limited insight into the role of survivin in the musculoskeletal apparatus beyond the oncologic context has been gained through previous studies.

While insights have been gained through these studies, they have largely focused on a single penetration depth into the target tissue.

Although Aotus and Saimiri monkey models have provided useful information about P. vivax biology, most of the data have been gained through comparative studies investigating polymorphisms in orthologous genes encoding resistance to pyrimethamine (dhfr gene), sulfadoxine (dhps gene), or chloroquine (chloroquine resistant transporter or mdr-1 genes).

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