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Although considerable experience has been gained in model updating, the critical issues that remain are the choice of parameters and how to deal with ill-conditioning.
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Despite such limitations, we believe that the findings presented here emphasize the utility of combining simulation modeling and ambulatory data collection, and highlight the considerable value to be gained in model building, decision making and operational prioritization by adding duration-based measures into surveillance.
In addition, most previous data on the relation between cell death and NASH were gained in this respective model (Csak et al, 2011; Hatting et al, 2013).
As a result, accuracy in estimating survival and the total number of children living with HIV may be gained in revising the model to reflect most recent estimates emerging from large cohort collaborations that represent mortality trends in a number of different regions across the world.
The ASP model has been gaining in popularity, since it allows businesses to run many of their complex software applications off the ASP's servers rather than their own, which means they don't have to worry about upgrades, bug patches and technical problems.
Finally, the parsimony-based reconstruction of binding site evolution infers that the Stat3 site (track #8, matching the STATx binding site model) was gained in mammals, lost in eutheria, and re-gained in rodents and monkeys (Simiiformes).
The LFO and LRD models adequately described the BTCs but a slight improvement in curve-fitting was gained in some cases when the NFO model was used.
Some insight into this possibility was gained in the chronic pancreatitis prone KrasG12D mouse model in which exenatide therapy accelerated formation and growth of dysplastic intraepithelial neoplasia (PanIN) lesions as well as pancreatitis (8).
The review also suggests that the more complex model specifications (e.g. response mapping or mixture models) are gaining in popularity and highlights a variety of model specifications that have been used in a small number of studies and warrant further investigation.
While certain existing theoretical response models are gaining in sophistication - as demonstrated by theories of long-span bridge response to wind - some of the gaps to be filled therein are mentioned.
Murder was gaining in respectability.
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