In particular for GR, important insight was gained from experiments in yeast, that characterised FKBP52 as stimulatory GR cofactor, while FKBP51 had no effect [18].
Early insights were gained from experiments using genetically engineered mammalian models and from studies manipulating HIF pharmacologically in humans.
Given the nature of experiments, however, it is not even always certain that all information for interested variables can be gained from experiments and not all metabolites in the large-scale pathway can be measured.
Additional evidence for the role of Arg175 was gained from experiments with 1,2-cyclohexanedione (1,2-CHD) that (reportedly) specifically and reversibly modifies arginyl residues (Patthy and Smith 1975 a, b ).
Much of our knowledge of genetics has been gained from fruit fly experiments and of population biology from flour beetle studies.
These mechanisms have not yet been investigated for CSFV, and most of the current knowledge has been gained from in vitro experiments.
More insight into the functions of BMP has been gained from in vivo experiments using transgenic animals to reflect the importance of BMP in osteogenesis.
Important insights into the molecular consequences of aberrant AE expression have been gained from microarray and chromatin immunoprecipitation experiments.
While significant knowledge has been gained from various large-scale investigations, more experiments are needed to uncover the details of the functions of genes involved in different cellular processes.
Further knowledge could be gained from animal experiments by assessing complete follow-ups until the end of the growth period.
