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ULS1 has been functionally linked with the SUMO pathway, whereas MOT3 and MIT1 each encode transcriptional regulators that contain prion-like domains (Alberti et al. 2009).

Third, among the broad spectrum of extracellular ligands that trigger RAGE signalling, many have been functionally linked with acute and chronic immune responses [ 24- 26].

We were intrigued by the ability of 2μ ULS1 to suppress mot1-301 becalthoughhoULS1ULS1 has been functionally linked with the SUMO pathway, it is proposed to be another STUbL that functionally overlaps with Slx5-Slx8.

Notably, a mis-activation of p63 in squamous cell carcinomas has been functionally linked with the activation of the FGFR2 receptor (61), further supporting the view that FGFs participate in Pin1-dependent p63 stability.

Interestingly, the filipin-stained structures partially associated with vertical F-actin-based columns (Supplementary Fig S11) suggestive of podosomes that form constitutively in M2 macrophages (Linder & Wiesner, 2015) and have been functionally linked with lysosomes (Cougoule et al, 2005; Tu et al, 2008).

Moreover, NEFH promoter methylation in esophageal squamous cell carcinoma (ESCC) has been functionally linked with loss of expression and activation of the v-akt murine thymoma viral oncogene homolog (AKT /β-catenin pAKT /β-cateninading to increased glycolysis rates and changes in mitochondria 27.

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Future studies in Dictyostelium might reveal additional genes that are functionally linked with ddTpp1 and will provide a better understanding of the physiological functions of TPP1, which is crucial for developing future therapies for NCL.

As illustrated in Fig. 3, there were multiple regions where correlations failed to reach the selected statistical threshold, but which may nonetheless be functionally linked with item-level semantic processing of objects.

These results are consistent with the hypothesis that NREM sleep is functionally linked with specializations of the amygdala, including perhaps memory processing.

One hour after injection of AuNPs into mouse tail vein, we detected significant gold signal in healthy mouse alveoli (Fig. S7B) as well as in GFP+ human alveoli (Fig. 4F), indicating the regenerated human tissues are functionally linked with circulation system.

One would have seen a differential in the level of recognition if the members of the pair could not be functionally linked with half-millisecond precision.

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