Subsequently, NEFH was functionally identified to exhibit attributes of a tumor suppressor as knockdown experiments revealed increased tumorigenicity in mice while expression of NEFH was associated with diminished cell growth and reduced colony formation in vitro 27.
To our knowledge, secretin and secretin receptors have only been functionally identified in mammals while a secretin-like peptide sequence has been isolated in chicken [36] [38].
To date, only a tiny fraction of plant nsLTPs have been functionally identified, and even fewer have been identified in maize [ Zea mays (Zm)].
Belonging to a protein family consisting of four members (Bestrophin1 4), hBest1 has been functionally identified as a Ca2+-activated Cl− channel (CaCC) in heterologous studies10,11,12,13,14,15.
In Botrytis cinerea and Neurospora crassa, D-galacturonic acid transporter proteins have been functionally identified (Benz et al. [2014]; Zhang et al. [2013]).
In human peripheral nerves, both transient and persistent Na+ currents have been functionally identified [24], [28] [30].
Jatropha FATB had also previously been functionally identified [ 8, 26].
Unlike SIRT1, SIRT5 is less well characterized and only carbamoyl phosphate synthetase 1 (CPS1) has been functionally identified as a SIRT5 substrate.
In the ensuing years, some members of nsLTPs have been functionally identified in plant species, including the involvement of cuticular waxes and cutin syntheses [ 12].
Gray matter enlargement was observed in areas that have been functionally identified as important in social-cognitive processes, such as the medial frontal gyri, sensorimotor cortex and middle temporal gyrus.
