We hypothesized that the murine orthologue, AKAP150, could be a potential modulator of glucose homeostasis, as previous studies have shown that this anchoring protein is functionally coupled to G protein-coupled receptors, adenylyl cyclases and ion channels (Gao et al, 1997; Fraser et al, 2000; Bauman et al, 2006).
RNA precursor splicing and transcription elongation are traditionally deemed to function separately, but increasing evidence suggests that splicing is functionally coupled to transcription elongation [ 36].
To investigate whether the activity in the motor cluster (as revealed by the interaction term) is functionally coupled to brain areas associated with body/movement perception, functional connectivity between this motor cluster and EBA/pSTS/FBA was assessed by computing PPIs.
These results suggest that β3-AR in human brown adipocyte is functionally coupled to lipolysis (Jockers et al., 1998).
Capping is functionally coupled to transcription by RNA polymerase (Pol) II, but the coupling mechanism remains unclear.
Although xylem hydraulics has been extensively studied, until recently, comparatively little is known quantitatively about the phloem hydraulic network and how it is functionally coupled to the xylem network, particularly in photosynthetic leaves.
As such, feline lung contains significant amounts of UT mRNA and this receptor appears to be functionally coupled to bronchoconstriction (the peptidic tool compound GSK248451 representing a sub-nanomolar inhibitor of such effects).
It has been argued that agonist ligands for dopamine D2/3 receptors recognize a privileged subset of the receptors in living striatum, those which are functionally coupled to intracellular G-proteins.
Recent studies in which such switches have been readily identified from combinatorial protein libraries support the notion that proteins are primed to show allosteric behavior and that newly created ligand-binding sites will often be functionally coupled to the original activity of the protein.
Syndecan-1 being functionally coupled to integrins has been demonstrated in other models [34].
