Only postmenopausal women were included, because the IHC4-C score has not yet been fully validated in premenopausal women.
However, the morphology, vulnerability, and distribution of coronary atherosclerosis in prediabetic patients have not yet been fully validated.
While individual brief questions may have been validated, the composite tool has not yet been fully validated against a complied gold standard, although this work in underway.
However, the technique has not yet been fully validated and it involves surgery under general anaesthesia (Hertel, 2010; Koh et al, 2013).
Without specific protein amplification techniques such as PCR for nucleic acids, the identification of biomarkers requires technologies which have not yet been fully validated.
Thus, there is a need to slow down the progression of SSc, but the efficacies of several therapeutic modalities, that have been assessed in clinical trials, have not yet been fully validated.
The advent of F18 amyloid binding radiotracers has established the feasibility of amyloid brain imaging at most sites with PET scanners, but this is an expensive undertaking that has not yet been fully validated.
Recently, several observational studies have used immunosuppressive agents, such as mycophenolate mofetil and rituximab, to delay or modify the disease course of SSc, but the therapeutic efficacies of these agents have not yet been fully validated [ 17- 19].
