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The mechanisms of rituximab resistance have not yet been fully elucidated, although both tumor- and host-associated resistance mechanisms have been proposed.
PGP's aetiology is still unknown and the underlying mechanisms have not been fully elucidated although mechanical, traumatic, hormonal, metabolic, and degenerative factors have been proposed [ 1, 2].
This observation is important, but has not been fully elucidated although it is in line with observations made in two previous analyses.
Signaling pathways influenced by PDT have not been fully elucidated, although a number of studies have addressed this issue [ 5, 10, 19].
The mechanism by which ATEN lowers BP has not been fully elucidated, although it is thought that the primary mechanism is through reduced cardiac output via a reduction in heart rate.
The patho-mechanisms of chemotherapy-related oral mucositis have not been fully elucidated, although considerable progress has been made during the last decade in defining a cascade of destructive and inflammatory events [ 3].
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For most antimalarial drugs neither mode of action nor mechanisms of resistance development are fully elucidated although this would be important prerequisites for successfully developing urgently required novel antimalarials.
The biochemical properties and physiological functions of the PSGs remain to be fully elucidated, although functional experiments and clinical observations are beginning to provide some clues.
At present the impact of these differences in binding affinity on the interpretation of the PET signal remains to be fully elucidated although it may be expected that low-affinity binding sites should lead to an underestimation of TSPO.
The function of these nucleolar caps within the DDR has yet to be fully elucidated, although PML has been shown to influence p53 activity by sequestering MDM2 at the nucleolus.
The mechanism whereby generating TDP-43 pathology, although has not been fully elucidated, is believed to be closely involved in the ALS pathogenesis.
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been fully clarified although
been fully understood although
been fully explained although
been fully determined although
been fully characterized although
been fully established although
been fully examined although
been fully resolved although
been fully defined although
been fully achieved although
been fully seen although
been fully met although
been fully sequenced although
been fully assessed although
been fully recovered although
been fully documented although
been fully explored although
been fully restored although
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