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Firstly, the high specificity and affinity of intrabodies to target antigens is well-established, whereas iRNA has been frequently shown to exert multiple non-specific effects.
Pre-pulse inhibition (PPI) of the startle response is a measure of sensorimotor gating which has been frequently shown to be deficient in schizophrenic patients.
In rodents, the CLP model has been frequently shown to produce AKI demonstrable both on functional and structural level [49-53] [49-53]
Impaired cognitive function in late-life depression and MRI white-matter hyperintensities have been frequently shown to be associated with the outcome of clinical treatment for depression [2, 15].
For still larger datasets, RAS has been frequently shown to be inferior to other strategies such as the parsimony ratchet.
The fast search approach (no branch swapping) has been frequently shown to yield considerably lower support values [ 12- 15].
Similar(47)
Aggregate stability is frequently shown to be enhanced by strong soil water repellency, however, there is limited systematic evidence on this effect for moderately (subcritically) water repellent soils.
However, runny/blocked noses and coughing are frequently shown to be the most often occurring respiratory symptoms [ 11, 41, 42].
On the other hand, patients with CAD were frequently shown to have impaired renal function, which may contribute to worse clinical outcomes [ 7– 10].
In conclusion, hypoxia was frequently shown to increase p53 protein level, with HIF-1 α and MDM2 being probably involved in most cases.
We speculate that this occurs preferably at sites of α5β1 and ανβ3 integrins, which were frequently shown to colocalize with concentrated spots of TG2 (Gaudry et al. 1999b; Telci et al. 2008; Zemskov et al. 2011).
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