Sentence examples for been fraught with considerable from inspiring English sources
Conventional longitudinal osteotomy design for its harvest has been fraught with considerable complications at the donor site including fracture clavicle and major neurovascular injury.
The current techniques of derivation of a wave spectrum from given values of design wave parameters, like significant wave height and average wave period, are fraught with considerable uncertainties.
10, 72 This review has demonstrated that the achievement of an accurate assessment of influenza vaccine effectiveness is fraught with considerable methodological and epidemiological challenges.
Nonetheless, we believe that most instances of guessing whether a chemical would eventually induce cancer in experimental animals and hence represent a carcinogenic hazard to humans are fraught with considerable uncertainty: uncertainty that can only be relieved by long-term testing for carcinogenicity in animals or by conducting an epidemiologic investigation of exposed individuals or groups.
However, such methodology can be fraught with difficulty, primarily related to the considerable uncertainty regarding the potential events after follow-up and, more specifically, around the handling of censored data and the correct approach to parameterisation of survival estimates.
