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For other species, the PAM AAY has been found using computational methods.
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This third approach is limited because mutations may have occurred in the PAMs since the original acqusition of the protospacer and hence acquisition and interference motifs cannot be distinguished (e.g., for S. mutans, the PAM WAAR was found using computational methods and YAAAWY in phage challenge experiments [ 6]).> -wrap-foot> The PAM orientation is displayed arbitrarily.
The computational complexity of the cluster merging phase involves merging clusters that were found using the attractor vertices.
If such domain knowledge is unavailable, one can find using computational methods.
High level of intrinsic disorder and a substantial number of potential interaction sites were also found using a set of computational tools.
Serovar-specific targets were found through computational comparative genomic analysis using BLAST.
For 77 of trans-encoded sRNAs significant sequence and secondary structure conservation was found by a computational approach using a whole genome alignment with the closely related species C. efficiens YS-314 and C. diphtheriae NCTC 13129.
The computational results have been found to be satisfactory.
After extensive computational testing setting α to 0.2 has been found to be a reasonable choice.
For N > 400, solutions are found in R using the package "gurobi" due to the computational complexity of larger problems.
In business we are beginning to understand that markets often follow rules that can be discerned using computational analysis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com