Rgs7 is predominantly expressed in the brain and has been found to shuttle between the cytoplasmic membrane and the nucleus, thus playing a role in gene expression in response to external stimuli [50].
Most prominently, the receptor tyrosine kinases (RTKs), and among them the members of the epidermal growth factor receptor (EGFR) family, have been found to shuttle to the nucleus in response to ligand binding (reviewed by Carpenter and Liao and Wang et al. ).
The device enabled her group to determine the function of a protein associated with severe Alzheimer's disease – the protein was found to shuttle and help store calcium ions in organelles called endosomes and lysosomes, and calcium levels were significantly decreased in tissue samples from patients severe forms of this disease.
Moreover, p68 was found to shuttle in and out of SC35 domains, forming fibers and granules in a cell-cycle dependent manner [23].
The first construct codifies for ERK1 minus its N-terminus and was found to shuttle at the same speed of ERK2: because of the conversion of its trafficking properties into those of ERK2 we labelled it as E1>E2 (figure 8, 9).
Although erythrocyte DARC served as a chemokine reservoir during EAE, brain endothelial DARC was found to shuttle recombinant chemokines from the abluminal to the luminal side of an in vitro blood brain barrier model.
Specifically, metformin has been found to inhibit the glycerophosphate shuttle enzyme mitochondrial glycerophosphate dehydrogenase (mGPD).
RACK1 has been found to act as both anchor and shuttle for a number of cellular proteins, including conventional PKC (protein kinase C) isoforms, dynamin-1, Ras-GAP (GTPase-activating protein), Src and several integrin receptors, as well as a variety of viral proteins [ 8].
LDH activity has previously been found to account for the majority of the NADH-oxidising activity when compared with the malate-aspartate shuttle in transformed cells [ 34].
Oxamate also has previously been found to inhibit purified AAT, an enzyme involved in mitochondrial metabolism via the tricarboxylic acid cycle and the malate-aspartate shuttle [ 17, 28].
CAPE CANAVERAL, Fla., July 3 — NASA officials said today that the agency would continue to prepare for a launch of the space shuttle Discovery Tuesday afternoon, even though a piece of foam insulation was found to have broken off the shuttle's external fuel tank.
