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This study identifies a striking similarity between EPEC and the carcinogenic bacterium Helicobacter pylori, which has also been found to downregulate MSH2 and MLH1 expression in human cell lines [54].
Some cytokines, including IL-6 and interferon-γ, have been found to downregulate the gene expression of sucrase isomaltase.
Finally, β1-adrenergic stimulation by high-dose terbutaline has been found to downregulate alveolar fluid clearance in the ex vivo rat lung [ 79].
Whereas ZA repolarizes macrophages to nitric-oxide-producing M1 macrophages, progesterone has been found to downregulate nitric oxide synthase activity in bone marrow macrophages [ 41].
AR signals have also been found to downregulate the expression of P450 CYP4B1 [ 27], UDP-glucuronosyltransferases (UGTs) [ 28], and GATA3 [ 29], all of which are known to prevent urothelial tumorigenesis.
The HDACi vorinostat has been found to downregulate RAD50 and MRE11 protein levels in prostate cancer and lung adenocarcinoma cells; furthermore, 72-h incubation causes decreased levels of 53BP1 in prostate cancer cells (Lee et al, 2010).
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Finally, the β-catenin/TGF/LEF complex is found to downregulate the expression of p16INK4a (suggesting another mechanism for p16 downregulation apart from methylation), as well as of miR-15a/16 miR-15a/16 in both furesultingegulatinn of cyclin D1 and increased angiogenesis in MM.
The Nsp2-targeted siRNA was found to downregulate the expression of Nsp2 in MARC-145 cells and inducing replication reduce of PRRSV in MARC-145 cells.
P19 RNAi was found to downregulate nm23-H1 protexpressionseen (see Figure S5) This finding strongly points to a role for p19 as a putative metastasic protection factor.
Collagen I protein coating was found to downregulate collagen I expression and upregulate COMP expression.
Atiprimod (Atiprimod) was found to downregulate IL-6 production (Bradbeer et al, 1996).
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