Moreover, it has been found that mutation of Apc [28] or NXT2 [29] of zebrafish showed that expression of bmp4 and versican genes are upregulated and that domains are expanded throughout the hearts.
Scientists at the University of Utah first cloned these genes after it was found that mutations in the BRCA1 and BRCA2 genes were linked to various types of breast and ovarian cancer.
By passaging the Fujian-like viruses in chicken eggs, it was found that mutations in HA not in NA improve the replication of the virus in chicken eggs and these mutations also increase HA binding activities to the avian receptors.
In summary, it was found that mutations rendering the SUB cSUBmut:EGFP construct nonfunctional also resulted in nonfunctional SUB gSUBmut:EGFP constructs, as corresponding SUB gSUBmut:EGFP sub-1 plants showed no rescue of the sub mutant phenotype (an example is given in Figure 6D).
It was found that mutations that cause disorder tendencies to flip to structure tendencies are the most likely mutations in disordered regions to be disease-causing [ 5].
It was found that mutations in this candidate gene, KRAS, are one of the most frequent genetic abnormalities in ovarian carcinoma [ 49].
It was found that mutations leading to EGFR overexpression have been associated with many cancers, including lung cancer, anal cancers, and glioblastoma multiforme [ 25, 26].
It was found that mutations in telomerase-related genes (TERT, TERC and DKC1) are responsible for the diseases in 15% of familial cases.
It is found that mutations in the MT-ATP6 gene result in neuropathy, ataxia, and retinitis pigmentosa, which lead to muscle weakness, vision loss, and the other features.
Early on, it was found that mutations affecting RNAi function in C. elegans and Drosophila melanogaster produced apparently normal organisms, but that these mutations increased the susceptibility of mutated animals to infection by viruses [ 5, 6].
