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DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases.
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Only low levels of the CHL1/CSP complex were found in synaptic plasma membranes, while this fraction was enriched in the CHL1/Hsc70/αSGT complex (Fig. 3D,F).
In favour of the latter hypothesis, this marker were found in synaptic vesicle preparations where the purity was confirmed using electron microscopy [26].
The typical cytochrome b561 family members are found in synaptic and other intracellular vesicles and the plasma membrane and have been implicated in neuronal functions [60], [61].
Nerve transporters are found in synaptic vesicles and sent by exocytosis to the other synapse.
Typical vacuoles in the grey matter (Figs. 3A and G) were found in synaptic regions in all cases.
Normally, DNAJC5 is found in synaptic vesicles, where it is involved in polymerization of dynamin (Zhang et al., 2012).
Furthermore C9ORF72 is found in synaptic-rich cellular fractions.
Interactions between multiple cells, mediated by fast synaptic mechanisms, have been found in the medial prefrontal cortex of rats [32].
Synaptic degeneration has been found in the brains of AD patients, which may be the underlying cause of memory impairment [ 56, 57].
For example, synaptic vesicles have been found in many non-neuronal cells including pinealocytes [ 120], chromaffin [ 121, 122] and pancreatic beta cells [ 123].
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